Together with the Melnick group at WCMC, we’ve just published a new study in the journal Blood in which we mapped DNA methylation genome-wide in >60 diffuse large B cell lymphoma samples and showed for the first time that the DNA methylation of only 15 promoters can accurately predict the two major DLBCL subtypes (ABC and GCB). This is highly relevant because these two subtypes have very distinct survival outcomes, with patients with ABC-type DLBCL having significantly worse prognostic than GCB-type.
http://bloodjournal.hematologylibrary.org/cgi/reprint/blood-2010-05-285320v1
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