The very first issue of this exciting new journal is out:
http://genomemedicine.com/
Seminars in Computational and Systems Biomedicine at the ICB January 25, 2009
I am co-organizing the new Seminars in Computational and Systems Medicine. David Botstein was our inaugural speaker and both talking to him and hearing his seminar about the coordination of growth rate, cell cycle, stress response and metabolic activity in yeast has been a fantastic experience (his seminar was much more thought-provoking than it sounds).
We are very pleased and honored to have the following speakers coming next :
February 6 – Isidore Rigoutsos
March 6 – Jason Mezey
April 3 – Olga Troyanskaya
May 15 – Dana Pe’er
June 26 – Alexandre Morozov
The seminars will be held in LC-504 (1300 York Avenue, 5th floor). All seminars will be on Fridays at 3pm. You can email me at ole2001@med.cornell.edu for more information.
Discovering gene fusions in cancer using deep sequencing January 15, 2009
Chinnaiyan and colleagues have combined 454 and Solexa sequencing to identify transcripts resulting from gene fusion, both in cancer cell lines and primary tumors. The approach relies on deep sequencing the cancer transcriptome and looking for reads that show partial alignment to exon boundaries from different genes. When applied to prostate cancer cell lines and tumors, it detects the well-known TMPRSS-ERG fusion but also discover several novel fusions. It is likely that this approach will lead to the discovery of many novel oncogenes in the near future.
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature07638.html
